I was looking at using the RGBW xml for a project and went to you tube looking for something, don't remember what, and found a video of a guy that maybe used a driver he built, I'm not sure. Anyway, he had it dancing and making all kinds of colors, it was pretty cool. So to answer that question yes it's possible.
To throw in a little more input. I've not seen a higher voltage RGBW LED. I've also not seen a buck driver with four outputs, like the one for this LED. Doesn't mean these things don't exist though.